Sun exposure may worsen some of the drying and irritating effects of retinol, according to the Skin Cancer Foundation.

Ironically, sun exposure could put you at risk for some of the same exact effects you’re using retinol for, such as age spots and wrinkles. To reduce such risks, wear a mineral-based sunscreen  whenever you plan to spend long periods outside.

It’s generally recommended that pregnant individuals avoid retinols. (Talk with your doctor about retinol if you think you’re pregnant or are planning on getting pregnant at some point soon).

Using retinol may aggravate eczema and rosacea. Avoid using it if you have an active case of either.